We investigated the link between plasma omega-3 levels and the risk of heart failure (HF) in a large UK cohort study. Our analysis revealed that higher omega-3 levels were associated with a 21% lower chance of developing HF over nearly 14 years.
For individuals already diagnosed with HF, elevated omega-3 levels corresponded to about a 50% reduction in the risk of overall and cardiovascular mortality. These results suggest that boosting omega-3 intake through diet or supplements may help prevent HF and increase longevity for those already facing heart challenges.
Read More
9
Omega-3 reduces cardiovascular risk
Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial.
We observed the effects of icosapent ethyl on heart health in a significant clinical trial involving statin-treated patients at high risk for cardiovascular events. This post hoc analysis revealed that icosapent ethyl reduced major cardiovascular issues, regardless of whether patients had low-density lipoprotein cholesterol (LDL-C) levels below or above 55 mg/dL.
Notably, those with optimal LDL-C control still benefited from the treatment, showing that this fish oil derivative can be effective in managing heart risks for many patients.
Read More
8
Eicosapentaenoic acid reduces arrhythmia
Eicosapentaenoic acid prevents atrial electrocardiographic impairments and atrial fibrillation in high fat diet mice.
We explored the impact of eicosapentaenoic acid (EPA) on heart health by studying mice on a high-fat diet. Those supplemented with EPA showed a significant reduction in atrial fibrillation compared to those without. While 100% of the high-fat diet mice developed atrial fibrillation, only 50% of those receiving EPA did, and their episodes were shorter.
Our findings suggest that including EPA in the diet can help improve heart function and reduce irregular heart rhythms linked to high-fat diets.
Read More
Most Useful Reviews
7.5
Supports cardiovascular health
491 people found this helpful
Strengthening the cardiovascular system, Omegas from this company have been incredibly effective for me! Each product has its merits, and this one stands out for support in the cardiovascular system due to its high EPA content. For brain activity enhancement, opt for Omega with higher DHA, although this also has a substantial DHA level. Please like if you found my review helpful!
Read More
9
Lowers bad cholesterol
240 people found this helpful
Omega-3 is excellent for reducing the risk of cardiovascular disease; it combats bad cholesterol and regulates blood pressure. It aids in weight control and promotes hair health. After extended use, I've noticed my hair quality improved and my bad cholesterol decreased slightly. This Omega thins the blood well, beneficial for my heart. After starting Omega, my hair has shone and split less.
Read More
9
Improves vascular health
122 people found this helpful
Omega-3, identified by Danish scientist Dayerberbu, shows that northern peoples' fish-based diets contribute to longevity and health. These fatty acids prevent cardiovascular disease and improve metabolic processes. A shortage of omega-3 can lead to dangerous cholesterol levels. Omega-3 enhances blood vessel elasticity, may prevent allergic and skin diseases, and has antioxidant properties, reducing cancer risk. If you found this review helpful, please click YES!
We observed the effects of icosapent ethyl on heart health in a significant clinical trial involving statin-treated patients at high risk for cardiovascular events. This post hoc analysis revealed that icosapent ethyl reduced major cardiovascular issues, regardless of whether patients had low-density lipoprotein cholesterol (LDL-C) levels below or above 55 mg/dL.
Notably, those with optimal LDL-C control still benefited from the treatment, showing that this fish oil derivative can be effective in managing heart risks for many patients.
Read More
9
Omega-3 improves heart function
The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis.
We assessed how omega-3 fatty acids (PUFAs) can support heart failure management through a thorough network meta-analysis of 14 studies with nearly 9,100 participants.
Our findings revealed that high doses (2,000-4,000 mg/day) taken for at least one year significantly improved heart function, particularly the left ventricular ejection fraction and peak oxygen consumption.
However, lower doses and shorter durations were not effective, and we found no major differences in safety measures like dropout rates or overall mortality between those taking omega-3 and those who were not.
Read More
9
Omega-3 levels reduce heart failure
Association of Plasma Omega-3 Levels With Incident Heart Failure and Related Mortalities.
We investigated the link between plasma omega-3 levels and the risk of heart failure (HF) in a large UK cohort study. Our analysis revealed that higher omega-3 levels were associated with a 21% lower chance of developing HF over nearly 14 years.
For individuals already diagnosed with HF, elevated omega-3 levels corresponded to about a 50% reduction in the risk of overall and cardiovascular mortality. These results suggest that boosting omega-3 intake through diet or supplements may help prevent HF and increase longevity for those already facing heart challenges.
Read More
9
Krill oil may improve heart health
Antarctic Krill Oil Supplementation Attenuates Hypercholesterolemia, Fatty Liver, and Oxidative Stress in Diet-Induced Obese Mice.
We delved into how Antarctic krill oil, rich in eicosapentaenoic acid (EPA), can influence cardiovascular health, specifically in the context of obesity. Our focus centered on its effects in mice fed a high-fat diet, which typically leads to increased cholesterol levels and oxidative stress—conditions that can heighten cardiovascular disease risk.
Through our research methods, including molecular docking and analysis of liver histology, we discovered that Antarctic krill oil appears to play a beneficial role in combating these adverse effects. We observed that the oil reduced oxidative stress and fat accumulation in these obese mice. This was associated with improved metabolic parameters that contribute to heart health, primarily through its action on molecules involved in cholesterol metabolism.
Notably, we found that krill oil helped lower the levels of harmful low-density lipoprotein cholesterol and activated pathways that support good cholesterol management in the body. These findings suggest that incorporating Antarctic krill oil, with its high EPA content, might be a promising strategy for addressing obesity-related cardiovascular issues.
Overall, our study points to the potential of eicosapentaenoic acid from krill oil as a natural approach to improving heart health, particularly for those struggling with obesity and its challenges.
Read More
8
Omega-3s are safer for hearts
EPA and DHA acylcarnitines are less cardiotoxic than are saturated and monounsaturated long-chain acylcarnitines.
This study examined how different fatty acids affect heart health, particularly focusing on long-chain acylcarnitines. We found that saturated and monounsaturated acylcarnitines, especially one type called trans-elaidoylcarnitine, can significantly harm heart function and cell viability.
On the other hand, omega-3 derived acylcarnitines like eicosapentaenoylcarnitine and docosahexaenoylcarnitine showed minimal negative effects. In fact, they did not impair heart function or cell viability, suggesting that omega-3 fish oil might be a safer option for people with heart issues compared to other fatty acid sources.
Strengthening the cardiovascular system, Omegas from this company have been incredibly effective for me! Each product has its merits, and this one stands out for support in the cardiovascular system due to its high EPA content. For brain activity enhancement, opt for Omega with higher DHA, although this also has a substantial DHA level. Please like if you found my review helpful!
Read More
9
Lowers bad cholesterol
240 people found this helpful
Omega-3 is excellent for reducing the risk of cardiovascular disease; it combats bad cholesterol and regulates blood pressure. It aids in weight control and promotes hair health. After extended use, I've noticed my hair quality improved and my bad cholesterol decreased slightly. This Omega thins the blood well, beneficial for my heart. After starting Omega, my hair has shone and split less.
Read More
9
Improves vascular health
122 people found this helpful
Omega-3, identified by Danish scientist Dayerberbu, shows that northern peoples' fish-based diets contribute to longevity and health. These fatty acids prevent cardiovascular disease and improve metabolic processes. A shortage of omega-3 can lead to dangerous cholesterol levels. Omega-3 enhances blood vessel elasticity, may prevent allergic and skin diseases, and has antioxidant properties, reducing cancer risk. If you found this review helpful, please click YES!
Read More
9
Heart disease control
70 people found this helpful
This fish oil is fantastic! My family takes two capsules daily. Omega 3 is vital for preventing cardiovascular disease and also enhances brain function and immune response. The quality and affordability make NOW Foods a great choice.
Read More
9
Effective against disease
36 people found this helpful
Omega-3 is one of the best options for combating cardiovascular disease. I prioritise my health and that of my loved ones, so I choose it with confidence.
Cardiovascular disease (CVD) is a broad term that encompasses a range of heart and blood vessel disorders. This can include conditions such as coronary artery disease, which leads to heart attacks; cerebrovascular disease that results in strokes; and peripheral artery disease affecting blood flow to the limbs. The key risk factors for CVD often include high blood pressure, high cholesterol, obesity, smoking, a sedentary lifestyle, and diabetes. By identifying and managing these risk factors, individuals can significantly reduce their likelihood of developing cardiovascular problems.
Prevention and treatment strategies often involve lifestyle modifications such as adopting a heart-healthy diet rich in fruits, vegetables, whole grains, and lean proteins, alongside engaging in regular physical activity. In some cases, medications might be necessary to control blood pressure or cholesterol levels. Regular check-ups with a healthcare provider are essential for monitoring heart health, especially for individuals with a family history of CVD. Understanding the signs and symptoms of cardiovascular issues—like chest pain, shortness of breath, or fatigue—can help in seeking timely medical attention, ultimately leading to better outcomes.
Omega-3 fish oil is a nutritional supplement derived from the fatty tissues of fish, particularly fatty fish like salmon, mackerel, and sardines. It is rich in omega-3 fatty acids, which are essential fats that the body cannot produce on its own. The most significant types of omega-3s found in fish oil are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), both of which are known for their numerous health benefits. These include reducing inflammation, supporting heart health, and promoting brain function.
Incorporating omega-3 fish oil into your diet can be beneficial if you don’t consume enough fish regularly. Many health experts recommend oily fish as a part of a balanced diet due to their high omega-3 content. For those who find it difficult to include fish in their meals, fish oil supplements can offer a convenient alternative, providing the same essential fatty acids in concentrated form. However, it’s essential to choose high-quality supplements that are third-party tested for purity and potency to avoid contaminants such as heavy metals or other toxins that can impact health.
Omega-3 fish oil has long been touted for its potential cardiovascular benefits, and numerous studies support the notion that it can be helpful in managing overall heart health. Rich in EPA and DHA, the primary active components in fish oil, omega-3 fatty acids are known to reduce triglyceride levels, lower blood pressure, and may even decrease the risk of arrhythmias. Some research suggests that regular consumption of omega-3s can lead to a reduced risk of heart disease and stroke by improving vascular health and reducing inflammation in the body.
However, it's essential to approach this topic with a balanced perspective. While omega-3 supplements can be beneficial, they should not be seen as a standalone solution for cardiovascular disease. Incorporating omega-3s through diet—such as fatty fish like salmon, sardines, and mackerel—is preferable to relying solely on supplements. Moreover, if you're considering adding fish oil supplements to your routine, it's advisable to consult with a healthcare provider to ensure they fit within your complete cardiovascular health strategy, which should also include a nutritious diet, regular exercise, and other heart-healthy lifestyle choices.
According to user reviews, the timeframe for noticing results from Omega-3 supplements can vary significantly. Many users report experiencing benefits within a relatively short period. For instance, one user noted improvements in vision after just one week of taking the supplement (Read Review). However, a common trend is for users to mention a timeframe of around a month before experiencing more substantial effects, particularly in relation to cardiovascular health and overall wellness. For example, another review indicated a stabilization of blood pressure and reduced discomfort after a month of consistent use (Read Review).
Overall, while some individuals may notice benefits such as reduced cholesterol levels or improved heart health sooner, a month seems to be a reasonable estimate for more observable improvements in cardiovascular status after beginning supplementation. Users emphasize the importance of consistency in taking the supplement to maximize benefits, with many suggesting a daily intake as part of a long-term health regimen (Read Review). It’s essential, however, to maintain realistic expectations and consult healthcare professionals for personalized advice regarding supplementation.
When it comes to cardiovascular disease (CVD), omega-3 fatty acids, particularly in the forms of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are increasingly supported by scientific research. Numerous studies point to their role in reducing cardiovascular risks by improving lipid profiles, reducing inflammation, and enhancing heart function. For instance, one study reported that high doses of omega-3 fatty acids significantly improved heart function in heart failure patients, showcasing benefits such as increased left ventricular ejection fraction and peak oxygen consumption [7]. Furthermore, findings indicate that higher levels of omega-3 fatty acids correlate with a reduced risk of major cardiovascular events like sudden cardiac death, emphasizing their protective role against heart disease [20].
Additionally, omega-3 supplementation may lead to significant improvements in endothelial function in patients with coronary artery disease and those undergoing statin therapy, suggesting they can complement existing heart health treatments [18]. However, it's worth noting that while most studies support the health benefits of these fatty acids, ongoing research aims to clarify dosage and duration effects, as well as to understand the mechanisms of action in specific populations [7]. Overall, the evidence is strong and growing, making omega-3 fatty acids a worthwhile consideration for those looking to improve their cardiovascular health.
Based on user reviews, many individuals have reported a range of significant improvements in their symptoms after incorporating Omega-3 supplements into their daily routine. A recurring theme is the enhancement of cardiovascular health; users frequently mention reductions in bad cholesterol and improved blood pressure. One user specifically noted that after a month of consistent intake, their discomfort eased and blood pressure stabilized (Read Review) while another confidently stated that Omega-3 combat bad cholesterol effectively (Read Review).
Additionally, several reviews highlight benefits beyond heart health, including enhanced brain function, improved skin health, and even weight control. For instance, one reviewer shared that their hair quality improved significantly after using Omega-3 for an extended period, attributing enhanced shine and reduced split ends to the supplement (Read Review). Other users noted improvements in joint mobility (Read Review) and a boost in overall immune response. However, it's important to keep in mind that individual results can vary widely, and while many users find these supplements beneficial, personal experiences may differ.
Based on user reviews, many individuals have explored the combination of Omega-3 supplements with other products for managing cardiovascular disease, often reporting positive outcomes. Users frequently mention that Omega-3 significantly contributes to cardiovascular health and can enhance the effectiveness of other supplements when taken together. For instance, one user emphasized the importance of Omega-3 in regulating bad cholesterol and blood pressure, suggesting it works synergistically with other health measures to support overall heart health (Read Review). Another customer praised the supplement for its dual impact on cardiovascular health and brain function, implying that while Omega-3 is effective on its own, combining it with a comprehensive health regimen may amplify its benefits (Read Review).
Additionally, users indicate that relying solely on Omega-3 might not be enough for everyone. Several reviews suggest that individuals actively seeking to manage their cardiovascular health should consider using Omega-3 alongside other supplements, such as vitamins and minerals, for a more rounded approach. One reviewer stated that increasing Omega-3 intake alongside dietary changes led to improved cholesterol levels and overall wellness, underscoring the supplement's value in a broader health strategy (Read Review). This reflects a common sentiment among users who advocate for a holistic approach to supplementing for cardiovascular disease management.
For those looking to harness the heart-healthy benefits of omega-3 fatty acids, a robust body of research suggests an optimal dosing strategy of 2,000 to 4,000 mg per day of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). This dosage has been shown to significantly improve heart function over long-term supplementation periods—specifically, at least one year, as noted in various studies [7]. Higher doses appear to enhance parameters like left ventricular ejection fraction and peak oxygen consumption in individuals managing heart failure.
However, it’s crucial to note that while these high doses over extended periods can yield substantial cardiovascular health benefits, lower doses or shorter durations may not be effective. This reflects the importance of adhering to recommended dosages for omega-3 supplementation to truly realize its protective cardiovascular effects. Additionally, always consult healthcare providers to tailor any supplementation to individual health needs and conditions.
9
Improves vision health
5 people found this helpful
I felt effects on my vision quickly after buying this Omega-3 for cardiovascular support. After just one week of taking 4 capsules daily, I noticed significant lubrication in my eyes and improvement in vision. I could read without glasses, even in low light. It’s a quality product that works!
8
Reduced inflammation
22 people found this helpful
Due to work-related issues and persistent joint inflammation, my doctors advised high-dose fish oil for inflammation reduction. Scientific journals recommend adults over 50 to take over 1000mg of fish oil, especially those with circulatory issues. After a month of taking Omega 3, my discomfort has eased, and my blood pressure is more stable. I plan to keep purchasing it as the price is reasonable.
9
Cancer prevention benefits
32 people found this helpful
This omega-3 supplement contains fish oil concentrate rich in fatty acids that lower cholesterol and help prevent cardiovascular disease. It also reportedly slows tumour growth. Omega-3 is effective for skin issues and aids in healing ulcers. It can improve joint mobility and is vital for brain health. I recommend taking three capsules daily with meals. Please click "YES" if my review is helpful.
9
Lowers bad cholesterol
240 people found this helpful
Omega-3 is excellent for reducing the risk of cardiovascular disease; it combats bad cholesterol and regulates blood pressure. It aids in weight control and promotes hair health. After extended use, I've noticed my hair quality improved and my bad cholesterol decreased slightly. This Omega thins the blood well, beneficial for my heart. After starting Omega, my hair has shone and split less.
9
Heart disease control
70 people found this helpful
This fish oil is fantastic! My family takes two capsules daily. Omega 3 is vital for preventing cardiovascular disease and also enhances brain function and immune response. The quality and affordability make NOW Foods a great choice.
9
Lipid improvement
4 people found this helpful
Omega 3 lowers triglycerides and bad cholesterol while raising good cholesterol. Its benefits include preventing cardiovascular disease and improving overall lipid levels. I take it daily for heart health.
9
Omega-3 improves heart function
The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis.
We assessed how omega-3 fatty acids (PUFAs) can support heart failure management through a thorough network meta-analysis of 14 studies with nearly 9,100 participants.
Our findings revealed that high doses (2,000-4,000 mg/day) taken for at least one year significantly improved heart function, particularly the left ventricular ejection fraction and peak oxygen consumption.
However, lower doses and shorter durations were not effective, and we found no major differences in safety measures like dropout rates or overall mortality between those taking omega-3 and those who were not.
8
Eicosapentaenoic acid reduces heart risk
Omega-3 Fatty Acids as Potential Predictors of Sudden Cardiac Death and Cardiovascular Mortality: A Systematic Review and Meta-Analysis.
We examined how eicosapentaenoic acid (EPA), alongside other omega-3 fatty acids, might influence the risk of sudden cardiac death (SCD) and cardiovascular disease (CVD) mortality. Our analysis included findings from ten prospective cohort studies, involving over 310,000 participants and averaging 8.7 years of follow-up.
We found a promising inverse relationship between EPA levels in the blood and the incidence of SCD. Specifically, higher circulating levels of omega-3s were linked to a reduced risk. Our results indicated that individuals with high levels of combined omega-3 fatty acids (EPA, DHA, and DPA) had about 45% lower risk of SCD and CVD mortality compared to those with lower levels. This suggests that increasing our intake of omega-3s, particularly EPA, may contribute to heart health.
In summary, the evidence points towards a potential benefit of higher EPA levels in protecting against serious heart issues. While the overall understanding continues to evolve, these findings could guide future dietary recommendations and heart health strategies.
8
Eicosapentaenoic acid improves endothelial function
Clinical Significance of Serum Omega-3 Fatty Acids on Endothelial Function in Patients with Coronary Artery Disease Under Statin Therapy.
We aimed to explore how eicosapentaenoic acid (EPA) influences cardiovascular health, specifically its effects on endothelial function in patients dealing with coronary artery disease (CAD) while on statin therapy. Our study involved 150 patients who were receiving statins to lower their cholesterol levels and who had LDL cholesterol levels below 100 mg/dL.
By measuring serum omega-3 fatty acid levels, we assessed endothelial function using a technique called flow-mediated dilation (FMD) of the brachial artery. This method helps understand how well blood vessels are responding to blood flow. Among these patients, we identified 65 individuals with impaired FMD (less than 6%) who also had low EPA/arachidonic acid ratios. We then provided them with EPA therapy and reassessed their endothelial function after three months.
Our analysis revealed that higher levels of docosahexaenoic acid (DHA) and combined EPA plus DHA were linked to better FMD outcomes. Notably, after EPA treatment, the FMD percentage improved significantly from 3.7% to 4.1% among those with low EPA/AA ratios. This improvement was even more pronounced in patients who exhibited both low EPA/AA levels and high triglyceride levels.
In summary, our findings indicate that serum omega-3 fatty acids are connected to endothelial dysfunction in CAD patients on statin therapy. Moreover, EPA therapy shows promise in enhancing endothelial function, particularly in a subset of patients with specific biochemical profiles.
References
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Medoro A, Graziano F, Cardinale G, Voccola S, Zotti T, et al. The influence of FADS1 and ELOVL2 genetic polymorphisms on polyunsaturated fatty acid composition in response to fish oil supplementation. Lipids Health Dis. 2025;24:102. doi:10.1186/s12944-025-02513-w
Horii K, Ono K, Sumi T, Higashihara M, Zaima N, et al. Eicosapentaenoic acid prevents atrial electrocardiographic impairments and atrial fibrillation in high fat diet mice. J Physiol Sci. 2025;75:100014. doi:10.1016/j.jphyss.2025.100014
Dawczynski C, Drobner T, Weidauer T, Schlattmann P, Kiehntopf M, et al. Reduction of cardiovascular risk factors by the diet - Evaluation of the MoKaRi concept by a parallel-designed randomized study. Lipids Health Dis. 2025;24:88. doi:10.1186/s12944-025-02500-1
Aggarwal R, Bhatt DL, Steg PG, Miller M, Brinton EA, et al. Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial. J Am Heart Assoc. 2025;14:e038656. doi:10.1161/JAHA.124.038656
Mao Q, Tian X, Wang X, Xu H, Zhang Y, et al. Global burden of cardiovascular diseases attributable to diet low in seafood omega-3 fatty acids from 1990~2021 and forecasting the future trends: A population-based study. PLoS One. 2025;20:e0316767. doi:10.1371/journal.pone.0316767
Tseng PT, Zeng BY, Hsu CW, Liang CS, Stubbs B, et al. The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis. Adv Nutr. 2025;16:100366. doi:10.1016/j.advnut.2025.100366
Hemmati R, Bahrami Zanjanbar D, Shishesaz MI, Soleimani A, Yari T. The impact of Omega-3 supplementation on arrhythmia reduction in acute coronary syndrome patients: a randomized clinical trial. J Complement Integr Med. 2025;22:173. doi:10.1515/jcim-2024-0427
Wang Y, Wu G, Wang Y, Rehman A, Yu L, et al. Recent developments, challenges, and prospects of dietary omega-3 PUFA-fortified foods: Focusing on their effects on cardiovascular diseases. Food Chem. 2025;470:142498. doi:10.1016/j.foodchem.2024.142498
Dong S, Wang Y, Bian J, Chen H, Dong J, et al. The effect of omega-3 Polyunsaturated Fatty Acid (PUFA) prescription preparations on the prevention of clinical cardiovascular disease: a meta-analysis of RCTs. Nutr J. 2024;23:157. doi:10.1186/s12937-024-01051-y
Jawad MA, O'Keefe JH, Tintle N, O'Keefe EL, Franco WG, et al. Association of Plasma Omega-3 Levels With Incident Heart Failure and Related Mortalities. Mayo Clin Proc. 2024;99:1895. doi:10.1016/j.mayocp.2024.08.007
Brosolo G, Da Porto A, Marcante S, Capilupi F, Bertin N, et al. The role for ω-3 polyunsaturated and short chain fatty acids in hypertension: An updated view on the interaction with gut microbiota. Eur J Pharmacol. 2024;985:177107. doi:10.1016/j.ejphar.2024.177107
Lee YQ, Tan KH, Chong MF. Biomarkers of PUFA and cardiovascular risk factors and events in healthy Asian populations: a systematic review. Br J Nutr. 2024;132:1474. doi:10.1017/S0007114524002708
Li J, Nan W, Huang X, Meng H, Wang S, et al. Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy. EMBO Rep. 2024;25:5507. doi:10.1038/s44319-024-00271-x
Li ZH, Song WQ, Qiu CS, Li HM, Tang XL, et al. Fish oil supplementation, genetic susceptibility and risk of new-onset hypertension. Prev Med. 2024;189:108152. doi:10.1016/j.ypmed.2024.108152
Hamaya R, Cook NR, Sesso HD, Buring JE, Manson JE. A Bayesian Analysis of the VITAL Trial: Effects of Omega-3 Fatty Acid Supplementation on Cardiovascular Events. Am J Clin Nutr. 2025. doi:10.1016/j.ajcnut.2025.02.028
Liboriussen C, Nygaard L, Jensen JD, Schmidt EB, Glerup RI, et al. Low Plasma Marine N-3 Polyunsaturated Fatty Acids are Associated with Increased Risk of Cardiovascular Events in Patients Treated with Maintenance Hemodialysis. J Ren Nutr. 2025. doi:10.1053/j.jrn.2025.02.001
Yunoki K, Matsumi H, Miyoshi T, Kubo M, Hata Y, et al. Clinical Significance of Serum Omega-3 Fatty Acids on Endothelial Function in Patients with Coronary Artery Disease Under Statin Therapy. J Cardiovasc Dev Dis. 2025;12. doi:10.3390/jcdd12020060
Patil T, Gregory M, Savona N, Jarmukli N, Leonard CE. Evaluating the Real-World Safety of Icosapent Ethyl Versus Omega-3 Polyunsaturated Fatty Acid in Nationwide US Veterans Cohort: Examining Atrial Fibrillation and Bleeding Endpoints. Clin Drug Investig. 2025;45:69. doi:10.1007/s40261-024-01417-4
Kim JY, Kong SYJ, Jung E, Cho YS. Omega-3 Fatty Acids as Potential Predictors of Sudden Cardiac Death and Cardiovascular Mortality: A Systematic Review and Meta-Analysis. J Clin Med. 2024;14. doi:10.3390/jcm14010026
Lamon-Fava S. Associations between omega-3 fatty acid-derived lipid mediators and markers of inflammation in older subjects with low-grade chronic inflammation. Prostaglandins Other Lipid Mediat. 2025;176:106948. doi:10.1016/j.prostaglandins.2025.106948
Fukuda T, Nakajima T, Hasegawa T, Amano H, Arikawa T, et al. Relationship Between Serum ω-3 Polyunsaturated Fatty Acid Concentration and Fatty Acid Fraction of Epicardial Adipose Tissue in Patients With Cardiovascular Disease. Cureus. 2024;16:e73417. doi:10.7759/cureus.73417
O'Keefe EL, O'Keefe JH, Abuissa H, Metzinger M, Murray E, et al. Omega-3 and Risk of atrial fibrillation: Vagally-mediated double-edged sword. Prog Cardiovasc Dis. 2024. doi:10.1016/j.pcad.2024.11.003
Choi JH, Park SE, Kim S. Antarctic Krill Oil Supplementation Attenuates Hypercholesterolemia, Fatty Liver, and Oxidative Stress in Diet-Induced Obese Mice. Nutrients. 2024;16. doi:10.3390/nu16213614
So J, Yao JH, Magadmi R, Matthan NR, Lamon-Fava S. Sex differences in lipid mediators derived from omega-3 fatty acids in older individuals with low-grade chronic inflammation. Prostaglandins Leukot Essent Fatty Acids. 2024;203:102655. doi:10.1016/j.plefa.2024.102655
Choi GY, Calder PC. The differential effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors: an updated systematic review of randomized controlled trials. Front Nutr. 2024;11:1423228. doi:10.3389/fnut.2024.1423228
Follonier C, Rabassa G, Branca M, Carballo D, Koskinas K, et al. Eligibility for marine omega-3 fatty acid supplementation after acute coronary syndromes. Atheroscler Plus. 2024;58:1. doi:10.1016/j.athplu.2024.09.002
Koutsaliaris IK, Pantazi D, Tsouka AN, Argyropoulou O, Tellis CC, et al. Differential Effect of Omega-3 Fatty Acids on Platelet Inhibition by Antiplatelet Drugs In Vitro. Int J Mol Sci. 2024;25. doi:10.3390/ijms251810136
Ren Y, Chen B, Zhang H, Xu S. A cohort study reveals shared and distinct serum metabolic biomarkers for major adverse cardiovascular events in middle-aged and older adults. Geroscience. 2025. doi:10.1007/s11357-025-01544-6
Arghavani H, Bilodeau JF, Rudkowska I. Association Between Circulating Fatty Acids and Blood Pressure: A Review. Curr Nutr Rep. 2025;14:15. doi:10.1007/s13668-024-00602-3
Li J, Guo J, Yuen M, Yuen H, Peng Q. The comparative effects of ω-7 fatty acid-rich sea buckthorn oil and ω-3 fatty acid-rich DHA algal oil on improving high-fat diet-induced hyperlipidemia. Food Funct. 2025;16:1241. doi:10.1039/d4fo04961f
Berkowitz L, Echeverría G, Salazar C, Faúndez C, Coe CL, et al. Lipidomic Signature of Healthy Diet Adherence and Its Association with Cardiometabolic Risk in American Adults. Nutrients. 2024;16. doi:10.3390/nu16233995
Shi F, Chowdhury R, Sofianopoulou E, Koulman A, Sun L, et al. Association of circulating fatty acids with cardiovascular disease risk: analysis of individual-level data in three large prospective cohorts and updated meta-analysis. Eur J Prev Cardiol. 2025;32:233. doi:10.1093/eurjpc/zwae315